инструкция асперин Method of use of aspirinA single dose of the drug can be used three times a day, the interval between doses should be within 4-8 hours. Patients with impaired liver and kidney function should either increase the interval between doses, or reduce the dose.According to the instructions to aspirin dose depends on the application: with feverish, pain, rheumatic diseases for children over 5 years of single dose of 0,25-0,75 g (not more than 1,5 grams per day) , a single dose for adults should not exceed 1 g, and daily — 3 g; for secondary prevention of infarction and unstable angina, the daily dose should be between 300-325 mg; when the migraine attack a single dose — 1 g (no more than 3 grams per day); violations of cerebral circulation Aspirin given at a dose of no more than 300 mg per day.Tablets should be taken before meals, swallowed whole with water or dissolved in water. The use of aspirin for more than three days without a doctor's prescription is strictly prohibited.Side effectsAccording to the instructions, Aspirin can cause some adverse reactions, such as: — Anorexia, nausea, epigastric pain (anterior abdomen); — Erosive ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding and hemorrhage; — Anemia, thrombocytopenia; — Bronchospasm (in patients with bronchial asthma); — Skin rash.ContraindicationsThe instructions to the aspirin indicated a number of diseases in which the use of the drug is illegal: asthma provoked by intake of salicylates and non-steroidal anti-inflammatory drugs; erosive and ulcerative disease of the gastrointestinal tract; concurrent use of aspirin with methotrexate weekly dose of 15 mg; bleeding diathesis; hepatic and renal failure; angina; hypertension; decompensated severe heart failure; enlargement of the thyroid gland.Aspirin is not assigned to the first and third trimesters of pregnancy, lactation, children under 15 years of age who have severe viral infections, respiratory diseases, as well as persons with hypersensitivity to salicylates.